Cerebral hemodynamics measured with diffuse optical spectroscopies to elucidate mechanisms of cognitive dysfunction after mild traumatic brain injury (Conference Presentation)

Erin M. Buckley

doi:10.1117/12.2546970

10 March 2020 Cerebral hemodynamics measured with diffuse optical spectroscopies to elucidate mechanisms of cognitive dysfunction after mild traumatic brain injury (Conference Presentation)

Erin M. Buckley

Author Affiliations +

Proceedings Volume 11253, Biomedical Applications of Light Scattering X; 1125308 (2020) https://doi.org/10.1117/12.2546970
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Near infrared spectroscopy (NIRS) combined with diffuse correlation spectroscopy (DCS) enable non-invasive, bedside assessment of brain blood flow and metabolism. In numerous disease states (e.g., stroke, traumatic brain injury) these hemodynamic parameters are deranged, and these derangements have diagnostic and/or prognostic value. However, to best utilize NIRS/DCS data to guide patient care, we need a mechanistic understanding of the molecular changes underlying hemodynamic and metabolic dysfunction. Using a mouse model of repetitive mild traumatic brain injury, we present an example of how preclinical studies with NIRS/DCS can aid in the interpretation and utility of clinical NIRS/DCS datasets.

Conference Presentation

Citation Download Citation

Erin M. Buckley "Cerebral hemodynamics measured with diffuse optical spectroscopies to elucidate mechanisms of cognitive dysfunction after mild traumatic brain injury (Conference Presentation)", Proc. SPIE 11253, Biomedical Applications of Light Scattering X, 1125308 (10 March 2020); https://doi.org/10.1117/12.2546970

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