Label-free ultrasensitive detection of Amyloid-β using microtoroid resonators with lipid surface functionalization (Conference Presentation)

Adley Gin; Phuong-Diem Nguyen; Judith Su

doi:10.1117/12.2550381

10 March 2020 Label-free ultrasensitive detection of Amyloid-β using microtoroid resonators with lipid surface functionalization (Conference Presentation)

Adley Gin, Phuong-Diem Nguyen, Judith Su

Author Affiliations +

Proceedings Volume 11258, Frontiers in Biological Detection: From Nanosensors to Systems XII; 112580A (2020) https://doi.org/10.1117/12.2550381
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Accurate measurement of Amyloid-β biomarkers in blood serum has been highly sought after for early detection of Alzheimer’s Disease (AD). However, non-specific binding and low levels of Amyloid-β in blood pose a problem for traditional immunoassays. Here, we propose a lipid-functionalized biosensor for real-time, label-free detection of Amyloid-β by interaction with whispering gallery modes (WGM) of a microtoroid optical resonator. Non-specific binding is reduced by uniform surface coverage of the lipid, and protein-lipid interactions enhance the shift in resonance frequency. The lipid surface functionalization scheme enables increased accuracy and sensitivity of Amyloid-β and potential for blood-based screening of AD.

Conference Presentation

Citation Download Citation

Adley Gin, Phuong-Diem Nguyen, and Judith Su "Label-free ultrasensitive detection of Amyloid-β using microtoroid resonators with lipid surface functionalization (Conference Presentation)", Proc. SPIE 11258, Frontiers in Biological Detection: From Nanosensors to Systems XII, 112580A (10 March 2020); https://doi.org/10.1117/12.2550381

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