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Glaucoma, Cataract, Age-related macular degeneration, (AMD) Diabetic retinopathy (DR) are among the leading retinal diseases. Thus, there is an active effort to create and develop methods to automate screening of retinal diseases. Many CAD (Computer Aided Diagnosis) systems have been expanded and are widely used for ocular diseases. Recently, Deep Neural Networks (DNNs) have been adopted in ophthalmology and applied to fundus images, achieving detection of retinal abnormalities using retinal images. There are essentially two approaches, the first one is based on hybrid method that employs image processing for preprocessing, features extraction and post processing and Deep Neural Network (DNN) is only used for classification. The second is the fully method where DNN is used for both feature extraction and classification. Several DNN models and their variants have been proposed such as AlexNet, VGG, GoogleNet, Inception, U-Net, Residual Net (ResNet), DenseNet for detection of eye retina abnormalities. The aim of this work is to provide the background and the methodology to conduct a benchmarking analysis including the computational aspects and analysis of the representative DNNs proposed in the state of the art for detection DR diseases. For each DNN different characteristics and some performance indices (i.e. model complexity, computation complexity, inference time, memory use) and detection disease performance (i.e. accuracy rate), must be taking into account to find the more accurate model. The public domain datasets used for training and testing the DNN models such as Kaggle, MESSIDOR, and EyePACS are outlined and analyzed in particular in DR detection.
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