Numerical simulation of optical coherence tomography interference signal occurring in the intravascular space under a layer of soft biological tissue

A. Yu. Potlov; S. V. Frolov; S. G. Proskurin

doi:10.1117/12.2563858

9 April 2020 Numerical simulation of optical coherence tomography interference signal occurring in the intravascular space under a layer of soft biological tissue

A. Yu. Potlov, S. V. Frolov, S. G. Proskurin

Author Affiliations +

Proceedings Volume 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine; 114571R (2020) https://doi.org/10.1117/12.2563858
Event: Saratov Fall Meeting 2019: VII International Symposium on Optics and Biophotonics, 2019, Saratov, Russian Federation

Abstract

А numerical simulation algorithm of the interference signal acquired from biological fluids’ flow in Doppler optical coherence tomography (OCT) system is described. The suggested numerical approach has four key features: i) hydrodynamic characteristics of the part of the geometric layout in the intravascular space are not static, but dynamically change in numerical simulation of the photon transport; ii) dynamic changes include fluctuations of the optical characteristics and geometry of the parts of the intravascular space and were made for all pixels (B-scan) or voxels (Cscan) of the acquired data; iii) pixels and voxels of the intravascular space are considered to have the optical properties either of blood plasma or of the red blood cells; iv) the flow velocity is different for different types of pixels (voxels) which replace each other in the intravascular space: v) velocity value is chosen to obtain the desired shape of the flow velocity profile. The numerical model of the flow with a complex structure in soft biological tissues was implemented as the dedicated software using the LabVIEW package. The interference signal (A-scan) simulating software was successfully tested using hydrodynamic phantoms and can be used to study flow characteristics and their dynamic changes.

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A. Yu. Potlov, S. V. Frolov, and S. G. Proskurin "Numerical simulation of optical coherence tomography interference signal occurring in the intravascular space under a layer of soft biological tissue", Proc. SPIE 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine, 114571R (9 April 2020); https://doi.org/10.1117/12.2563858

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KEYWORDS

Optical coherence tomography

Blood

Numerical simulations

Tissue optics

Monte Carlo methods

Geometrical optics

Signal processing

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