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5 March 2021 Photobiomodulation at the level of single neural cells in culture
Ljiljana Durdevic, Julien Savatier, Aroa Relano-Gines, Laura Auboyer, Serge Monneret, Guillaume Blivet, Guillaume Baffou
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Proceedings Volume 11628, Mechanisms and Techniques in Photodynamic Therapy and Photobiomodulation; 116280B (2021) https://doi.org/10.1117/12.2578427
Event: SPIE BiOS, 2021, Online Only
Abstract
Recently, we introduced a novel treatment of Alzheimer's disease (AD) consisting of the use of photobiomodulation (PBM) coupled with a static magnetic field . The efficiency of this approach was evidenced on a model of mice affected by a neurotoxic agent (Amyloid-β(25-35)). In this communication, we will present recent results using this approach at the scale of neural cells in culture, as an attempt to enhance the benefit of light starting from a much simpler model than an entire mammalian organism. We will highlight the interest of using imaging instead of ensemble fluorescence measurements, and comment on parameters such as the PBM wavelength, fluence and glutamate concentration.
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Ljiljana Durdevic, Julien Savatier, Aroa Relano-Gines, Laura Auboyer, Serge Monneret, Guillaume Blivet, and Guillaume Baffou "Photobiomodulation at the level of single neural cells in culture", Proc. SPIE 11628, Mechanisms and Techniques in Photodynamic Therapy and Photobiomodulation, 116280B (5 March 2021); https://doi.org/10.1117/12.2578427
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KEYWORDS
Alzheimer's disease
Luminescence
Dementia
Interferometry
Magnetism
Optical microscopes
Organisms
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