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5 March 2021 Development and functional characterization of retinal dystrophy model using targeted layer-specific laser microirradiation
Michael Carlson, Sanghoon Kim, Subrata Batabyal, Samarendra K. Mohanty
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Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 1162915 (2021) https://doi.org/10.1117/12.2586105
Event: SPIE BiOS, 2021, Online Only
Abstract
We combine the real-time structural imaging capability of OCT with laser microirradiation for causing layer-specific dystrophies to mimic Retinitis Pigmentosa and dry-AMD model. In addition, we integrated an ERG-module for functional characterization after laser-injury to monitor the disease progression as well as to evaluate therapeutic efficacy. Here, we show creation of local atrophies with our combined OCT-Laser-ERG system in animal models and measurement of different cone and rod responses to focal stimulation light of different wavelengths. By varying the different mode of laser microirradiation and focal adjustment to the targeted depth, we demonstrate layer specific primary RPE injury.
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Michael Carlson, Sanghoon Kim, Subrata Batabyal, and Samarendra K. Mohanty "Development and functional characterization of retinal dystrophy model using targeted layer-specific laser microirradiation", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 1162915 (5 March 2021); https://doi.org/10.1117/12.2586105
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KEYWORDS
Animal model studies
Visual process modeling
Retina
Cones
Injuries
Optogenetics
Pathophysiology
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