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5 March 2021 Fiber biosensor based on a combination of refractive-index-sensing optical comb with chemical surface modification
Takuya Nakahara
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Proceedings Volume 11635, Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXI; 116350M (2021) https://doi.org/10.1117/12.2583197
Event: SPIE BiOS, 2021, Online Only
Abstract
Recently, we have proposed a refractive-index(RI)-sensing optical comb by placing a multi-mode interference (MMI) fiber sensor inside a fiber comb cavity. In this method, change of RI is read out as a repetition frequency frep via photonic RF conversion, and is precisely measured based on a RF frequency standard. If a surface of the intracavity MMI sensor is chemically modified for biosensing, it will be further used for biosensing. In this paper, we chemically modified the surface of the intracavity MMI fiber sensor with biotin and then read the chemical reaction with avidin as a change in frep.
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Takuya Nakahara "Fiber biosensor based on a combination of refractive-index-sensing optical comb with chemical surface modification", Proc. SPIE 11635, Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXI, 116350M (5 March 2021); https://doi.org/10.1117/12.2583197
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KEYWORDS
Biosensors
Fiber optics sensors
Brain-machine interfaces
Biosensing
Refractive index
Chemical reactions
Optical testing
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