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High Q whispering gallery mode optical resonators are capable of rapid and ultra-sensitive biological detection at attomolar concentrations in under 30 seconds. One main question in the field is how these sensors detect such low concentrations of molecules so quickly. Calculations based on diffusion alone suggest that transport to these sensors should take hours to days. Here, we show using bromothymol blue dye flow visualization methods that transport to a microtoroid optical resonator can take place in seconds. We reconcile these results with finite element simulations.
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Sartanee Suebka, Phuong-Diem Nguyen, Adley Gin, Judith Su, "Flow visualization of analyte transport to microtoroid optical resonators," Proc. SPIE 11637, Microfluidics, BioMEMS, and Medical Microsystems XIX, 116370H (5 March 2021); https://doi.org/10.1117/12.2578973