Design and development of a functional diffuse optical tomography probe for real-time 3D imaging of tissue

Manob Jyoti Saikia

doi:10.1117/12.2577433

5 March 2021 Design and development of a functional diffuse optical tomography probe for real-time 3D imaging of tissue

Manob Jyoti Saikia

Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 116391Q (2021) https://doi.org/10.1117/12.2577433
Event: SPIE BiOS, 2021, Online Only

Conference Poster

Abstract

Diffuse optical tomography is a non-invasive medical imaging method that quantitatively reconstructs threedimensional optical absorption and scattering coefficient distribution of imaging tissue domain. Functional diffuse optical tomography (fDOT) system uses multiple-wavelength near-infrared (NIR) light sources, and by reconstructing the variation of the absorption coefficient inside the tissue for these wavelengths, it maps the concentration of various constituents such as oxygenated and deoxygenated blood, water and lipids inside the tissue. This manuscript discusses the development of a 3D tissue scanning system based on fDOT principle. A configurable optical fiber probe was designed that can be placed on a tissue surface to inject modulated NIR light into the tissue from one of the three wavelengths (660, 735, and 850 nm) by light-emitting diodes (LED). The intensity of the back-reflected diffused light is measured using detector fibers coupled with a set of photodetectors. A microcontroller-based electronic circuit system and a dedicated DAQ unit perform system control, data acquisition, noise-free lock-in detection, and wireless data transmission to a host computer, equipped with a graphics processing unit (GPU). The GPU system executes a 3D fDOT spectroscopic image reconstruction software in real-time. Extensive simulation studies have been carried out for the 3D fDOT image reconstruction to study the concentration of chromophores such as oxyhemoglobin, deoxyhemoglobin, and water, and to characterize tumor located deep inside the tissue. The results from two different experimental setups validated the system. The promising results pave the way for the development of a low-cost 3D fDOT handheld system for the real-time onsite functional imaging of biological tissue.

Conference Presentation

Citation Download Citation

Manob Jyoti Saikia "Design and development of a functional diffuse optical tomography probe for real-time 3D imaging of tissue", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 116391Q (5 March 2021); https://doi.org/10.1117/12.2577433

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