Evaluating the impact of melanin on spectral colouring in photoacoustic imaging

Thomas R Else; Lina Hacker; Sarah E. Bohndiek

doi:10.1117/12.2577257

5 March 2021 Evaluating the impact of melanin on spectral colouring in photoacoustic imaging

Thomas R Else, Lina Hacker, Sarah E. Bohndiek

Proceedings Volume 11642, Photons Plus Ultrasound: Imaging and Sensing 2021; 116424M (2021) https://doi.org/10.1117/12.2577257
Event: SPIE BiOS, 2021, Online Only

Conference Poster

Abstract

Spectral colouring severely affects quantification in photoacoustic imaging, impacting the biological interpretation of the output imaging biomarkers. Melanin is a particularly strong optical absorber in the near infrared wavelength range that exhibits substantial variation in concentration according to skin tone. Here, Monte-Carlo simulations of light transport in a computational skin phantom were carried out to establish the effects of quantifying blood oxygenation at different melanin concentrations. These results were validated with a tissue-mimicking phantom. The results demonstrated that raised melanin concentration in the epidermis significantly affects quantification of haemoglobin concentration and oxygenation with photoacoustic imaging.

Conference Presentation

Citation Download Citation

Thomas R Else, Lina Hacker, and Sarah E. Bohndiek "Evaluating the impact of melanin on spectral colouring in photoacoustic imaging", Proc. SPIE 11642, Photons Plus Ultrasound: Imaging and Sensing 2021, 116424M (5 March 2021); https://doi.org/10.1117/12.2577257

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available