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5 March 2021 Focal dynamic thermal imaging for label-free detection of cancer in preclinical models
Christine M. O'Brien, Hongyu Meng, Leonid Shmuylovich, Julia Carpenter, Praneeth Gogineni, Haini Zhang, Kevin Bishop, Suman B. Mondal, Gail P. Sudlow, Cheryl Bethea, Clyde Bethea, Samuel Achilefu
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Proceedings Volume 11651, Optical Diagnostics and Sensing XXI: Toward Point-of-Care Diagnostics; 116510R (2021) https://doi.org/10.1117/12.2583435
Event: SPIE BiOS, 2021, Online Only
Abstract
Dynamic thermal imaging has improved bulk tissue characterization, but fails to capture subtle thermal property differences in heterogeneous systems. We present focal dynamic thermal imaging (FDTI), a simple, label-free, and high-resolution technology for delineating tissue heterogeneity. Stimulation of focal regions of absorptive materials with a narrow beam, low power, and low cost 405 nm laser locally perturbs the thermal equilibrium. Measurement of phantoms, ex vivo tissue, and in vivo animal models of cancer reveals finite structures of materials and delineates diseased from healthy tissue. Portable FDTI holds promise to capture the heterogeneous nature of malignant tissue.
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Christine M. O'Brien, Hongyu Meng, Leonid Shmuylovich, Julia Carpenter, Praneeth Gogineni, Haini Zhang, Kevin Bishop, Suman B. Mondal, Gail P. Sudlow, Cheryl Bethea, Clyde Bethea, and Samuel Achilefu "Focal dynamic thermal imaging for label-free detection of cancer in preclinical models", Proc. SPIE 11651, Optical Diagnostics and Sensing XXI: Toward Point-of-Care Diagnostics, 116510R (5 March 2021); https://doi.org/10.1117/12.2583435
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KEYWORDS
Cancer
Thermography
Tissues
Thermal modeling
Tumor growth modeling
3D modeling
Tumors
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