Quantitative phase imaging of thick scattering samples through a flexible fiber-optic bundle

Zhe Guang; Patrick B. Ledwig; Paloma Casteleiro Costa; Francisco E. Robles

doi:10.1117/12.2576688

5 March 2021 Quantitative phase imaging of thick scattering samples through a flexible fiber-optic bundle

Zhe Guang, Patrick B. Ledwig, Paloma Casteleiro Costa, Francisco E. Robles

Proceedings Volume 11653, Quantitative Phase Imaging VII; 116531G (2021) https://doi.org/10.1117/12.2576688
Event: SPIE BiOS, 2021, Online Only

Conference Poster

Abstract

We demonstrate a fiber-based quantitative phase imaging (QPI) system with epi-illumination to acquire tissue and cellar level structure. Our approach is based on quantitative oblique back-illumination microscopy (qOBM), which keeps the advantages of QPI—label-free and non-destructive with nanometer-scale sensitivity—while also delivering tomographic sectioning capabilities in thick scattering samples using epi-illumination. The developed system uses a simple and robust configuration consisting of a flexible fiber bundle and a GRIN lens. Here data are presented with histopathological feature analysis. This technique, with its compact setup and real-time processing algorithm, can lead to in-vivo medical diagnosis, for clinical surgery and endoscopy.

Conference Presentation

Citation Download Citation

Zhe Guang, Patrick B. Ledwig, Paloma Casteleiro Costa, and Francisco E. Robles "Quantitative phase imaging of thick scattering samples through a flexible fiber-optic bundle", Proc. SPIE 11653, Quantitative Phase Imaging VII, 116531G (5 March 2021); https://doi.org/10.1117/12.2576688

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