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5 March 2021 Pancreatic islet characterisation by the hyperspectral Assessment of autofluorescence: a non-invasive, label-free measure of viability
Jared M. Campbell, Stacey N. Walters, Saabah B. Mahbub, Abbas Habibalahi, Ayad G. Anwer, Shane T. Grey, Ewa M. Goldys
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Proceedings Volume 11655, Label-free Biomedical Imaging and Sensing (LBIS) 2021; 1165506 (2021) https://doi.org/10.1117/12.2578220
Event: SPIE BiOS, 2021, Online Only
Abstract
Type 1 diabetes occurs when insulin secreting beta cells in pancreatic islets are destroyed leading to elevated glucose and ill health. Islet transplantation is an effective therapy, but islets are often damaged by the isolation process resulting in numerous, repeated transplants to achieve insulin independence. We have applied hyperspectral microscopy to damaged islets and have shown through the assessment of native cell autofluorescence we can detect heterogenous forms of damage (elevated ROS, inflammatory signalling and warm ischemia) in mouse islets. This approach has great potential to be translated clinically to minimise the burden of suboptimal islet transplantations.
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Jared M. Campbell, Stacey N. Walters, Saabah B. Mahbub, Abbas Habibalahi, Ayad G. Anwer, Shane T. Grey, and Ewa M. Goldys "Pancreatic islet characterisation by the hyperspectral Assessment of autofluorescence: a non-invasive, label-free measure of viability", Proc. SPIE 11655, Label-free Biomedical Imaging and Sensing (LBIS) 2021, 1165506 (5 March 2021); https://doi.org/10.1117/12.2578220
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KEYWORDS
Ischemia
Transplantation
Blood
Glucose
Hyperspectral imaging
Inflammation
Microscopy
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