Surface Enhanced Linear and Non-Linear Raman Spectroscopy Approaches for Biomedical Analysis

Jürgen Popp

doi:10.1117/12.2595547

7 March 2021 Surface Enhanced Linear and Non-Linear Raman Spectroscopy Approaches for Biomedical Analysis

Jürgen Popp

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Proceedings Volume 11658, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVIII; 1165803 (2021) https://doi.org/10.1117/12.2595547
Event: SPIE BiOS, 2021, Online Only

Abstract

Powerful detection schemes in bioanalytics are associated with molecular specificity, high sensitivity, high spatial resolution and fast detection times. Within this presentation we will demonstrate that surface enhanced Raman spectroscopy (SERS) is able to meet all those requirements. We start with introducing various SERS detection schemes (direct SERS, SERS labels, molecular sensors) to identify bacterial infections or for the detection of atherosclerotic plaques. At the end we will present a tip enhanced Raman approach (TERS) to identify nanometer small virus particles. In order to further enhance the detection limit a novel coherent anti-Stokes Raman scattering approach using tip-enhanced techniques will be introduced.

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Jürgen Popp "Surface Enhanced Linear and Non-Linear Raman Spectroscopy Approaches for Biomedical Analysis", Proc. SPIE 11658, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVIII, 1165803 (7 March 2021); https://doi.org/10.1117/12.2595547

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