Study of sodium depositions in heart interstitium using methods of X-ray absorption and X-ray fluorescence microscopy

Igor A. Artyukov; Grigori P. Arutyunov; Maksim A. Bobrov; Inna N. Bukreeva; Alessia Cedola; Dmitri O. Dragunov; Ruslan M. Feshchenko; Michela Fratini; Alessandra Gianoncelli; Vadim M. Mitrokhin; Anna V. Sokolova; Alexander V. Vinogradov

doi:10.1117/12.2593608

8 July 2021 Study of sodium depositions in heart interstitium using methods of X-ray absorption and X-ray fluorescence microscopy

Igor A. Artyukov, Grigori P. Arutyunov, Maksim A. Bobrov, Inna N. Bukreeva, Alessia Cedola, Dmitri O. Dragunov, Ruslan M. Feshchenko, Michela Fratini, Alessandra Gianoncelli, Vadim M. Mitrokhin, Anna V. Sokolova, Alexander V. Vinogradov

Author Affiliations +

Proceedings Volume 11886, International Conference on X-Ray Lasers 2020; 1188615 (2021) https://doi.org/10.1117/12.2593608
Event: XVII International Conference on X-Ray Lasers, 2020, Online Only

Abstract

To date there have been only indirect indications of the presence of bound sodium accumulation in muscle and skin tissues. Despite their osmotic inactivity, such sodium deposits can effect on mechanical properties of the heart muscle impairing its elasticity and leading to serious heart dysfunctions. In this work an accurate study of the chemical composition of the heart muscle tissue at the cellular level was carried out using the methods of X-ray absorption and fluorescence microscopy. The experiments were carried out on a TwinMic X-ray scanning microscope [3] at ELETTRA synchrotron (Italy) with a resolution of about 1 μm. Comparison of the obtained maps of intra- and extracellular sodium distribution in heart tissues of different laboratory animals has resulted in the first experimental confirmation of the hypotheses about the existence of deposited sodium states in the intercellular space. The paper demonstrates an example of the state-of-the-art medical applications of high spectral brilliance X-ray sources.

Citation Download Citation

Igor A. Artyukov, Grigori P. Arutyunov, Maksim A. Bobrov, Inna N. Bukreeva, Alessia Cedola, Dmitri O. Dragunov, Ruslan M. Feshchenko, Michela Fratini, Alessandra Gianoncelli, Vadim M. Mitrokhin, Anna V. Sokolova, and Alexander V. Vinogradov "Study of sodium depositions in heart interstitium using methods of X-ray absorption and X-ray fluorescence microscopy", Proc. SPIE 11886, International Conference on X-Ray Lasers 2020, 1188615 (8 July 2021); https://doi.org/10.1117/12.2593608

ACCESS THE FULL ARTICLE

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

Subscribe to Digital Library

Receive Erratum Email Alert

Keywords/Phrases

Search In:

Publication Years