Quantitative phase imaging with mixed-transfer-function for resolution enhancement

Linpeng Lu; Jiasong Sun; Jiaji Li; Yao Fan; Jialin Zhang; Qian Chen; Chao Zuo

doi:10.1117/12.2601160

9 October 2021 Quantitative phase imaging with mixed-transfer-function for resolution enhancement

Linpeng Lu, Jiasong Sun, Jiaji Li, Yao Fan, Jialin Zhang, Qian Chen, Chao Zuo

Proceedings Volume 11896, Advanced Optical Imaging Technologies IV; 118960K (2021) https://doi.org/10.1117/12.2601160
Event: SPIE/COS Photonics Asia, 2021, Nantong, JS, China

Abstract

Transport of intensity equation (TIE) is an established quantitative phase imaging (QPI) method derived from paraxial approximation, however, this approximation limits TIE to retrieve high-resolution QPI. Thus, we present a dark-field transport of intensity equation (DFTIE) approach to improve resolution, solving the attenuation and blurring at high frequencies, which is combined iterative TIE phase retrieval with high-angle illumination coherent-mode decomposition to improve the maximum resolution under low numerical aperture objective. Simulation results demonstrate that DFTIE can achieve high-contrast and high-resolution QPI over the whole theoretical bandwidth, showing efficiency for high-throughput imaging. With the simple mode (only bright-field and dark-field are required) and multiplexing illumination, the imaging signal-to-noise ratio is higher, offering a flexible and cost-effective alternative for biomedical research and cellular investigations.

Conference Presentation

Citation Download Citation

Linpeng Lu, Jiasong Sun, Jiaji Li, Yao Fan, Jialin Zhang, Qian Chen, and Chao Zuo "Quantitative phase imaging with mixed-transfer-function for resolution enhancement", Proc. SPIE 11896, Advanced Optical Imaging Technologies IV, 118960K (9 October 2021); https://doi.org/10.1117/12.2601160

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