Time-gated diffuse reflectance to discriminate optical properties of two-layered tissue phantoms

Carter McMaster; Michael Helton; Boyd Colbrunn; Mary-Ann Mycek; Karthik Vishwanath

doi:10.1117/12.2610392

3 March 2022 Time-gated diffuse reflectance to discriminate optical properties of two-layered tissue phantoms

Carter McMaster, Michael Helton, Boyd Colbrunn, Mary-Ann Mycek, Karthik Vishwanath

Proceedings Volume 11974, Biomedical Applications of Light Scattering XII; 119740C (2022) https://doi.org/10.1117/12.2610392
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Time-resolved diffuse optical spectroscopy (TRDOS) provides a method for directly and independently determining the optical transport coefficients of turbid media. A multispectral, gated TRDOS system was built using a supercontinuum laser source and a fast single photon avalanche photodiode (SPAD) for detection. Electronic time-gating of the SPAD allowed for detection of time-gated photon distributions, and showed an increase of nearly 80x in dynamic range relative to ungated detection. TRDOS measurements using both ungated and gated detection schemes on two-layer tissue mimicking phantoms were acquired. The distribution of time-of-flight (DTOF) of photons was measured from a two-layered tissue simulating phantom at multiple source-detector separations and wavelengths. Measured DTOFs were matched to predictions from diffusion-theory (DT) for two-layered media after numerical convolution with measured instrument response functions. We show a dependence of the two-layer DT model on the input values of the upper layer thickness and refractive indices. It was found that both the upper layer thickness and refractive index parameters must well-determined for DT predictions to match measurements in two-layer media.

Citation Download Citation

Carter McMaster, Michael Helton, Boyd Colbrunn, Mary-Ann Mycek, and Karthik Vishwanath "Time-gated diffuse reflectance to discriminate optical properties of two-layered tissue phantoms", Proc. SPIE 11974, Biomedical Applications of Light Scattering XII, 119740C (3 March 2022); https://doi.org/10.1117/12.2610392

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