Immunological effects of photodynamic therapy

Patricia M. Logan; Jo-anne Newton; Anna M. Richter; Stephen Yip; Julia G. Levy

doi:10.1117/12.17659

1 July 1990 Immunological effects of photodynamic therapy

Patricia M. Logan, Jo-anne Newton, Anna M. Richter, Stephen Yip, Julia G. Levy

Proceedings Volume 1203, Photodynamic Therapy: Mechanisms II; (1990) https://doi.org/10.1117/12.17659
Event: OE/LASE '90, 1990, Los Angeles, CA, United States

Abstract

There are few reports in the literature regarding the effect that photodynamic therapy (PDT) might have on immune function. illumination of skin with light in the long UV range is well known to have immunosuppressive properties mediated by the amplification of a subpopulation of T suppressor cells1. However, PDT effected by light at between 600 and 700 nm and accompanied by an acute inflammatory response has not been studied in depth in terms of its influence on immune function. A few recent reports have documented suppression of immune function in the days immediately following PDTZ3. In one report, the cells responsible for this suppressive effect were characterized as a non-T cell population which were incapable of adoptively transferring the effect2. It is probable that the cells responsible for transient immunosupppression following PDT are activated macrophages, no doubt stimulated by the photodynamic effect and well known for their release ofprostaglandin E2 which is non-specifically immunosuppressive. On the other hand, there is anecdotal evidence from clinical studies attesting to what might be interpreted as immunological enhancement following PDT (infiltration of lymphocytes into inflammatory lesions), as well as reports of elevated levels of interleukin 2 (IL-2) in the urine of patients treated with PDT for bladder cancer'5. Some investigators have reported lymphokine involvement in photodynamically initiated lesions6. Recent work by Gomer and his associates have shown positive correlation with PDT and enhanced natural killer cell activity7 and have suggested that this could play a role in reduction of the metastatic potential of surviving tumor cells8.

Citation Download Citation

Patricia M. Logan, Jo-anne Newton, Anna M. Richter, Stephen Yip, and Julia G. Levy "Immunological effects of photodynamic therapy", Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); https://doi.org/10.1117/12.17659

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available