Simulation of a MEMS cell delivery system by ultrasound

Cuimin Sun; Menghua Zhang; Hui You

doi:10.1117/12.2628525

16 February 2022 Simulation of a MEMS cell delivery system by ultrasound

Cuimin Sun, Menghua Zhang, Hui You

Proceedings Volume 12164, International Conference on Optoelectronic Materials and Devices (ICOMD 2021); 121640D (2022) https://doi.org/10.1117/12.2628525
Event: 2021 International Conference on Optoelectronic Materials and Devices, 2021, Guangzhou, China

Abstract

Ultrasound cell delivery has been intensively studied in the context of eukaryotic transformation and gene therapy in recent years. Most existing ultrasound DNA delivery techniques reported used macro volumes with conventional ultrasonic equipment like ultrasonic immersion horns or ultrasonic baths and the cell studies were carried out at population levels where only average analysis is possible (10⁵ –10⁷ cells). However, averaging the effects from cell-cycle-dependent states and inhomogeneous cellular responses contributes to difficulties in interpreting data. New technologies and devices that enable single-cell handling, precision analysis and ultra-sensitive detection are required. A MEMS ultrasound cell delivery device promising a lab-on-chip approach to ultrasound cell delivery has been proposed in this paper. To analytically prove the feasibility of this approach, the piezo-acoustic coupling modelling of the system has been carried out using COMSOL multiphysics and both its acoustics and MEMS modules. The output of the simulation result is very close to the analytical results in both the profile of the acoustic pressure distribution and peak values.

Citation Download Citation

Cuimin Sun, Menghua Zhang, and Hui You "Simulation of a MEMS cell delivery system by ultrasound", Proc. SPIE 12164, International Conference on Optoelectronic Materials and Devices (ICOMD 2021), 121640D (16 February 2022); https://doi.org/10.1117/12.2628525

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