Hyperspectral time-resolved compressive sensing spectroscopy for monitoring cytochrome-c-oxidase and blood oxygenation

Natalie C. Li; Seva Ioussoufovitch; Mamadou Diop

doi:10.1117/12.2649040

7 March 2023 Hyperspectral time-resolved compressive sensing spectroscopy for monitoring cytochrome-c-oxidase and blood oxygenation

Natalie C. Li, Seva Ioussoufovitch, Mamadou Diop

Author Affiliations +

Proceedings Volume 12376, Optical Tomography and Spectroscopy of Tissue XV; 123760E (2023) https://doi.org/10.1117/12.2649040
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Time-resolved (TR) near-infrared spectroscopy (NIRS) is a promising technique for neuromonitoring, but there are currently very few TR-NIRS devices with the spectral range and resolution needed for accurate monitoring of cerebral blood oxygenation (StO2) and metabolism (cytochrome-c-oxidase; oxCCO). Here we present a hyperspectral TR compressive sensing spectrometer with a wide spectral range, high spectral resolution, and no after pulsing. A homogeneous blood-yeast phantom experiment was performed to evaluate the spectrometer’s ability to monitor S_tO₂ and oxCCO with and without compression. The effect of using a 90% compression rate on the recovered changes in deoxyhemoglobin (Hb), oxyhemoglobin (HbO), and oxCCO concentrations was investigated. No meaningful differences were found between concentration changes recovered from uncompressed and compressed data, with mean differences of 0.16 ± 0.20 µM, -0.25 ± 0.21 µM, and -0.04 ± 0.10 µM for Hb, HbO, and oxCCO, respectively. The results show that changes in oxCCO and S_tO₂ can be reliably monitored with a high compression rate. Future work will compare the performance of the TR spectrometer with that of a continuous-wave spectrometer to assess accuracy and will investigate the sensitivity of the device to oxCCO and S_tO₂ changes in the bottom compartment of a 2-layer tissue-mimicking phantom.

Citation Download Citation

Natalie C. Li, Seva Ioussoufovitch, and Mamadou Diop "Hyperspectral time-resolved compressive sensing spectroscopy for monitoring cytochrome-c-oxidase and blood oxygenation", Proc. SPIE 12376, Optical Tomography and Spectroscopy of Tissue XV, 123760E (7 March 2023); https://doi.org/10.1117/12.2649040

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
12 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Spectroscopy

Chromophores

Compressed sensing

Spectral resolution

Blood

Near infrared spectroscopy

Time resolved spectroscopy

Keywords/Phrases

Search In:

Publication Years