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14 March 2023 Modulations of tumor-infiltrating γδT cells by localized ablative immunotherapy (Conference Presentation)
Kaili Liu, Ashley R. Hoover, Wei R. Chen
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Proceedings Volume 12380, Biophotonics and Immune Responses XVIII; 1238004 (2023) https://doi.org/10.1117/12.2651964
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
γδT cell has gained importance during tumor immunotherapy. However, the transcriptional alterations remain unknown. Here, we applied a novel localized ablative immunotherapy (LAIT) to treat tumors in MMTV-PyMT mice and used single-cell RNA-sequencing to investigate the transcriptional profiles regulated by PTT, GC and LAIT (PTT+GC) in γδT cells. Subtypes of γδT cells included activated, cytotoxic, cycling cytotoxic, interferon enriched, antigen-presenting cell (APC)-like, and IL17-expressing γδT cells. Treatments specifically induced cell proportion in Il17-γδT cells while not other subtypes. LAIT-induced Il17-γδT gene expressions were positively associated with breast cancer patients’ survival, highlighting the clinical applications of Il17-γδT for cancer therapies.
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Kaili Liu, Ashley R. Hoover, and Wei R. Chen "Modulations of tumor-infiltrating γδT cells by localized ablative immunotherapy (Conference Presentation)", Proc. SPIE 12380, Biophotonics and Immune Responses XVIII, 1238004 (14 March 2023); https://doi.org/10.1117/12.2651964
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KEYWORDS
Tumors
Modulation
Cancer
Breast cancer
Oncology
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