Cerebral hemodynamics monitoring during extracorporeal membrane oxygenation in piglets

C. Amendola; G. Cavallaro; G. S. Amelio; L. Provitera; G. Raffaeli; F. Mosca; L. Spinelli; A. Torricelli; D. Contini

doi:10.1117/12.2670871

9 August 2023 Cerebral hemodynamics monitoring during extracorporeal membrane oxygenation in piglets

C. Amendola, G. Cavallaro, G. S. Amelio, L. Provitera, G. Raffaeli, F. Mosca, L. Spinelli, A. Torricelli, D. Contini

Proceedings Volume 12628, Diffuse Optical Spectroscopy and Imaging IX; 126280F (2023) https://doi.org/10.1117/12.2670871
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

Critically ill neonates are subjected to severe and abrupt hemodynamic imbalances that could cause cerebral damage (e.g., hemorrhage, ischemic events). In this population, the need for cerebral monitoring tools to identify dangerous hemodynamic variations in real-time is paramount. Near-infrared spectroscopy (NIRS) is largely exploited in neonatal intensive care units (NICU) to monitor critically ill patients' cerebral oxygenation. However, the most used NIRS devices exploit continuous wave NIRS (CW NIRS) technique, which is affected by motion artifacts and has low penetration depth compared to other more complex NIRS techniques. Moreover, CW-NIRS does not allow the investigation of tissue perfusion. Thus, in this ongoing study, we tested a hybrid device that combines time-domain NIRS (TD-NIRS) and diffuse correlation spectroscopy (DCS) for monitoring absolute cerebral total hemoglobin concentration (tHb), cerebral tissue oxygen saturation (S_tO₂), and cerebral blood flow index (BFI) of piglets during induced hemodynamic variations. Cerebral hemodynamic variations were induced during extracorporeal membrane oxygenation (ECMO) procedure, simulating four common conditions affecting the cerebral hemodynamics of ill neonates: hypocapnia, hypercapnia, hypotension, and hypertension. We measured 4 piglets, and the preliminary results shown in this study are promising, obtaining hemodynamic variations in accordance with previous findings, and empowering the possibility to exploit hybrid TD-NIRS and DCS devices to assess cerebral health of ill neonates.

Citation Download Citation

C. Amendola, G. Cavallaro, G. S. Amelio, L. Provitera, G. Raffaeli, F. Mosca, L. Spinelli, A. Torricelli, and D. Contini "Cerebral hemodynamics monitoring during extracorporeal membrane oxygenation in piglets", Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX, 126280F (9 August 2023); https://doi.org/10.1117/12.2670871

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KEYWORDS

Hemodynamics

Near infrared spectroscopy

Oxygenation

Tissues

Cerebral blood flow

Continuous wave operation

Oxygen

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