Wide-field computational cellular-resolution imaging of the human retina using multi-MHz phase-stable SS-OCT

ByungKun Lee; Sunhong Jeong; Joosung Lee; Tae Shik Kim; Boy Braaf; Benjamin J. Vakoc; Wang-Yuhl Oh

doi:10.1117/12.2670648

11 August 2023 Wide-field computational cellular-resolution imaging of the human retina using multi-MHz phase-stable SS-OCT

ByungKun Lee, Sunhong Jeong, Joosung Lee, Tae Shik Kim, Boy Braaf, Benjamin J. Vakoc, Wang-Yuhl Oh

Author Affiliations +

Proceedings Volume 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V; 1263203 (2023) https://doi.org/10.1117/12.2670648
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

Three-dimensional (3D) cellular-resolution imaging of the living human retina over a large field of view would bring a great impact in clinical ophthalmology, potentially finding new biomarkers for early diagnosis and improving the pathophysiological understanding of ocular diseases. While hardware-based and computational Adaptive Optics (AO) Optical Coherence Tomography (OCT) have been developed to achieve cellular-resolution retinal imaging, these approaches support limited 3D imaging fields and their high cost, and their intrinsic hardware complexity limit their practical utility. Here, we demonstrate 3D depth-invariant cellular-resolution imaging of the living human retina over a 3-mm × 3-mm field of view using the intrinsically phase-stable multi-MHz retinal swept-source OCT and tailored computational defocus and aberration correction methods. Single-acquisition imaging of photoreceptor cells, retinal nerve fiber layer, and retinal capillaries is presented across unprecedented imaging fields. By providing wide-field 3D cellular-resolution imaging in the human retina using a standard point-scan architecture routinely used in the clinic, this platform proposes a strategy for expanded utilization of high-resolution retinal imaging in both research and clinical settings.

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ByungKun Lee, Sunhong Jeong, Joosung Lee, Tae Shik Kim, Boy Braaf, Benjamin J. Vakoc, and Wang-Yuhl Oh "Wide-field computational cellular-resolution imaging of the human retina using multi-MHz phase-stable SS-OCT", Proc. SPIE 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V, 1263203 (11 August 2023); https://doi.org/10.1117/12.2670648

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KEYWORDS

Retina

3D image processing

Stereoscopy

Optical coherence tomography

Retinal scanning

Clinical research

Computer hardware

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