A novel interface for cortical columnar neuromodulation with multi-point infrared neural stimulation

Anna W. Roe; Fei-Yan Tian; Ying Zhang; Kenneth E. Schriver; Jia-ming Hu

doi:10.1117/12.3008277

13 March 2024 A novel interface for cortical columnar neuromodulation with multi-point infrared neural stimulation

Anna W. Roe, Fei-Yan Tian, Ying Zhang, Kenneth E. Schriver, Jia-ming Hu

Proceedings Volume 12829, Optogenetics and Optical Manipulation 2024; 128290A (2024) https://doi.org/10.1117/12.3008277
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Traditional visual cortical prosthetics based on electrical stimulation have induced percepts low in spatial resolution and devoid of rich visual features. Here, using pulsed infrared neural stimulation (INS), a method that evokes perceived phosphenes in alert monkeys, we have developed an approach with the submillimeter spatial precision needed for interfacing with cortical columns. We delivered INS through a linear optic fiber array in anesthetized cat visual cortex and monitored effects by optical imaging in contralateral visual cortex. INS modulation of response to ongoing visual oriented gratings produced enhanced responses in orientation-matched domains and reduced response in non-matched domains. This oriented response is a higher order, integrated effect. Controls included dynamically applied speeds, directions and patterns of multipoint stimulation. This provides groundwork for a conceptually and technologically new generation of BMI, one based in the columnar code of visual featural perception.

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Anna W. Roe, Fei-Yan Tian, Ying Zhang, Kenneth E. Schriver, and Jia-ming Hu "A novel interface for cortical columnar neuromodulation with multi-point infrared neural stimulation", Proc. SPIE 12829, Optogenetics and Optical Manipulation 2024, 128290A (13 March 2024); https://doi.org/10.1117/12.3008277

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KEYWORDS

Visualization

Infrared radiation

Human-machine interfaces

Optical arrays

Visual cortex

Visual optics

Modulation

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