Multiphoton imaging of the formation of fluorescent advanced glycation end products in tissues

Sohidul Mondal; Chih-Ju Lin; Nasim Kamely; Sheng-Lin Lee; Jeon-Woong Kang; Peter T. C. So; Chen Yuan Dong

doi:10.1117/12.2691192

12 March 2024 Multiphoton imaging of the formation of fluorescent advanced glycation end products in tissues

Sohidul Mondal, Chih-Ju Lin, Nasim Kamely, Sheng-Lin Lee, Jeon-Woong Kang, Peter T. C. So, Chen Yuan Dong

Proceedings Volume 12847, Multiphoton Microscopy in the Biomedical Sciences XXIV; 1284708 (2024) https://doi.org/10.1117/12.2691192
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

At the present, the two clinical biomarkers used to monitor diabetic progression are blood glucose and HbA1c. However, advanced glycation end products (AGEs) have been shown to contribute to diabetic pathogenesis, and there is interest in the use of AGEs in tissues as long-term glycemic markers. In this study, we investigate the in vitro rate of fluorescent AGEs (fAGEs) formation with multiphoton microscopy in different porcine tissues (aorta, cornea, kidney, dermis, and tendon) from glucose, galactose, and fructose, three primary monosaccharides found in human diets. These results may be of value in developing long-term glycemic biomarkers for diabetes.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Sohidul Mondal, Chih-Ju Lin, Nasim Kamely, Sheng-Lin Lee, Jeon-Woong Kang, Peter T. C. So, and Chen Yuan Dong "Multiphoton imaging of the formation of fluorescent advanced glycation end products in tissues", Proc. SPIE 12847, Multiphoton Microscopy in the Biomedical Sciences XXIV, 1284708 (12 March 2024); https://doi.org/10.1117/12.2691192

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