Rapid production of liposome encapsulated J-aggregates of indocyanine green

Noah B. Stern; Binita Shrestha; Tyrone Porter

doi:10.1117/12.3001105

13 March 2024 Rapid production of liposome encapsulated J-aggregates of indocyanine green

Noah B. Stern, Binita Shrestha, Tyrone Porter

Proceedings Volume 12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV; 128620C (2024) https://doi.org/10.1117/12.3001105
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Liposomal J-Aggregates of Indocyanine Green (L-JA) offer significant advantages over conventionally used monomeric indocyanine green (IcG) for photoacoustic imaging. When compared to IcG, which is often hindered by low circulation time and poor photostability, L-JA are characterized by longer circulation times, vastly improved photostability, elevated absorption at longer wavelengths, and increased photoacoustic signal generation. However, the documented methods for production of L-JA varies widely, which can lead to significant batch variability. We developed an approach to form IcG J-aggregates (IcG-JA) directly in liposomes efficiently and reproducibly at elevated temperatures. Aggregating within fully formed liposomes ensures particle uniformity and allows for the control of J-Aggregate size within the final particle. This technique provides a more robust and facile approach to producing these viable agents.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Noah B. Stern, Binita Shrestha, and Tyrone Porter "Rapid production of liposome encapsulated J-aggregates of indocyanine green", Proc. SPIE 12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV, 128620C (13 March 2024); https://doi.org/10.1117/12.3001105

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