Application of CRISPR technology in the prevention and control of bacterial drug resistance

Yuting Sheng

doi:10.1117/12.3012860

8 January 2024 Application of CRISPR technology in the prevention and control of bacterial drug resistance

Yuting Sheng

Author Affiliations +

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129241E (2024) https://doi.org/10.1117/12.3012860
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

Clustered regularly interspaced palindromic repeats (CRISPRs), a recently identified interference route, are present in the majority of archaea and many bacteria. The resistance of CRISPR system to gram-negative (GN) and gram-positive (GP) bacteria has been developed. In this paper, the application of CRISPR technology in the prevention and control of bacterial drug resistance has been introduced. Replacement of toxin genes in SaPIs with antimicrobial drugs to produce antimicrobial drones (ABDs). Targeting infected bacteria in animal hosts to give lethal doses of Staphylococcus aureus to save mice. It is also used for Streptomyces to construct an edited plasmid for Streptomyces gene editing (GE) using pCRISPomyces-2 as the prototype plasmid. pCRISPomyees-2 can be used in Streptomyces to efficiently perform Streptomyces GE. Future research in molecular biology will benefit from the use of the CRISPR/Cas system to manage the horizontal transfer of drug resistance genes in bacteria. The use of CRISPR technology to modify pathogenic microorganisms and inhibit viral infection is of great significance to the prevention and treatment of infectious diseases.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Yuting Sheng "Application of CRISPR technology in the prevention and control of bacterial drug resistance", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129241E (8 January 2024); https://doi.org/10.1117/12.3012860

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KEYWORDS

Resistance

Bacteria

Pathogens

Genetics

Biomedical applications

Defense and security

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