The PD-1 and PD-L1 checkpoint and the application of their inhibitors

Hanqiu Li

doi:10.1117/12.3012850

8 January 2024 The PD-1 and PD-L1 checkpoint and the application of their inhibitors

Hanqiu Li

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129242K (2024) https://doi.org/10.1117/12.3012850
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

Immunotherapy has become a research hotspot in the field of tumor therapy due to its significant therapeutic effects. Since the discovery of PD-1/PD-L1, this pair of immune cell receptors and ligands has rapidly become an important area of research in tumor immunity and even immunology in general. Targeted drugs against PD-1/PD-L1 have also become an essential part of immunotherapy and provided new life opportunities for countless cancer patients. This article will review the background and significance of the discovery of PD-1/PD-L1, and systematically introduce their applications and related inhibitor drugs. On the other hand, although PD-1 and PD-L1 discoveries have had a groundbreaking impact on immunology, there are still some shortcomings and uncharted territories for their related targeted drugs. This article will show some of the drawbacks of the functions of PD-1/PD-L1 inhibitor drugs and future views of PD-1/PD-L1 related immune suppression treatments, in order to further understand its mechanism and provide new ideas for clinical treatment of malignant tumors.

Citation Download Citation

Hanqiu Li "The PD-1 and PD-L1 checkpoint and the application of their inhibitors", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129242K (8 January 2024); https://doi.org/10.1117/12.3012850

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