Breast cancer screening is a critical component of healthcare, engaging over 2.23 million women annually in the UK. The National Health Service Breast Screening Program requires breast screening readers to participate in the PERFORMS scheme for quality assurance and training. This study investigates the potential of a specificity-focused test set within PERFORMS to reduce false positive recalls and enhance readers’ image interpretation skills in England. The specificity set comprised 60 challenging breast screening cases, including 15 malignant and 45 benign/normal cases. Among the 529 participating readers in the pre-specificity (pre-SP) round, post-specificity (post-SP) round, or both, they were categorized as those who underwent the specificity set (n = 317) and those who did not (n = 212). The post-SP recall rate was significantly lower (36.0%) compared to the pre-SP rate (37.7%) (p = 0.000). This decrease was more pronounced in those who undertook the specificity set (-2.7%) than in those who did not (-0.5%) (p = 0.0018). The correct return to screen rate and positive predictive value (PPV) improved in the post-SP set, with rates of 86.4% and 76.0%, respectively, compared to 82.4% and 68.5% in the pre-SP set (p = 0.000). The increase in correct return to screen and PPV was comparable between those who undertook the specificity set and those who did not (p = 0.0933 and p = 0.2515, respectively). In conclusion, integrating a specificity-focused test set within PERFORMS shows promise in positively impacting breast screening reader performance, offering insights for future training and quality assurance enhancements.
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