Effectiveness of porphyrin-like compounds in photodynamic damage of atherosclerotic plaque

Viacheslav N. Zalessky M.D.; Vladimir Bobrov; Igor Michalkin; Vitaliy Trunov

doi:10.1117/12.44055

1 June 1991 Effectiveness of porphyrin-like compounds in photodynamic damage of atherosclerotic plaque

Viacheslav N. Zalessky M.D., Vladimir Bobrov, Igor Michalkin, Vitaliy Trunov

Proceedings Volume 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques; (1991) https://doi.org/10.1117/12.44055
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

Porphyrin-like compounds such as tetra-(4 sulfonatophenyl) porphine (TSPP), chlorin-e6 derivative (CED) and tetrasulfophthalocyanin (TSPC) are photosensitizing agents that absorbed light at 630 nm, 657 nm and 625 nm, respectively, and bind preferentially to atherosclerotic plaque. Porphyrin-treated human cadaveric aorta was compared with untreated aorta using several techniques: the absorptive spectrophotometry which has demonstrated the distinct absorptive peaks at 630 nm, 657 nm, 625 nm in porphyrin-treated plaque which were absent in untreated normal aorta; the fluorescence microscopy, which has shown that the treated atheroma acquired the characteristic fluorescence of porphyrin under ultraviolet light. Because of the porphyrin''s unique property, porphyrin-treated and untreated aorta was exposed to red laser radiation at a wavelength of 632.8 nm. It was found that enhanced photoalteration of porphyrin-treated compared with untreated atheroma. Histologic analysis of the depth of tissue penetration of equal amounts of laser radiation has demonstrated more pronounced photosensitizing effect in TSPC-treated plaque compared with CED-, TSPP-, and untreated plaques. This study demonstrates a potential of tetrasulfophthalocyanin for selective alteration of atheroma by He-Ne laser radiation.

Citation Download Citation

Viacheslav N. Zalessky M.D., Vladimir Bobrov, Igor Michalkin, and Vitaliy Trunov "Effectiveness of porphyrin-like compounds in photodynamic damage of atherosclerotic plaque", Proc. SPIE 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, (1 June 1991); https://doi.org/10.1117/12.44055

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Laser tissue interaction

Tumors

Ultraviolet radiation

Tissue optics

Tissues

Absorption

Luminescence

Show All Keywords

Keywords/Phrases

Search In:

Publication Years