Problem solving in pharmaceutical production using scanning infrared microprobe analysis

John A. Reffner

doi:10.1117/12.137753

14 August 1992 Problem solving in pharmaceutical production using scanning infrared microprobe analysis

John A. Reffner

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Proceedings Volume 1681, Optically Based Methods for Process Analysis; (1992) https://doi.org/10.1117/12.137753
Event: SPIE's 1992 Symposium on Process Control and Monitoring, 1992, Somerset, NJ, United States

Abstract

The infrared microprobe is a powerful analytical technology for problem-solving in the pharmaceutical industry, providing the problem-solver with a tool for analyzing organic and many inorganic materials at the microscopic level. While the most obvious application of the infrared microprobe is the analysis of contaminants and product defects, SIRM also provides a way of monitoring solid-state forms, states of hydration or solvation, identities of inclusions in crystals, polymorphism, and quantitative analysis of materials. Analyzing and monitoring packaging materials (which are often multi-layered polymer materials) is another major area of SIRM application. The instrumentation and applications for SIRM are presented.

Citation Download Citation

John A. Reffner "Problem solving in pharmaceutical production using scanning infrared microprobe analysis", Proc. SPIE 1681, Optically Based Methods for Process Analysis, (14 August 1992); https://doi.org/10.1117/12.137753

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