Determination of optimal parameters for argon-laser-assisted carotid anastomoses in rats: macroscopic, thermal, and histological evaluation

Veronique L. Martinot; Serge R. Mordon; Valerie A. Mitchell; P. N. Pellerin; Jean Marc Brunetaud

doi:10.1117/12.146237

28 May 1993 Determination of optimal parameters for argon-laser-assisted carotid anastomoses in rats: macroscopic, thermal, and histological evaluation

Veronique L. Martinot, Serge R. Mordon, Valerie A. Mitchell, P. N. Pellerin, Jean Marc Brunetaud

Author Affiliations +

Proceedings Volume 1879, Lasers in Urology, Gynecology, and General Surgery; (1993) https://doi.org/10.1117/12.146237
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

The aim of this study was to determine the optimal parameters for an Argon laser (spot diameter equals 200 micrometers ) to obtain and reproduce vessel anastomoses. It was performed in 2 groups of Wistar rats. In the first group (89 shots on 10 carotids), the fluence was continuously adjusted from 30 to 3,000 J/cm² in order to determine an optimal set of parameters (power from 90 to 200 mW, shot duration from 0.1 to 5 seconds, pulsed or continuous mode). In the second group, thirty end-to-end carotid anastomoses were evaluated by macroscopic, thermal and histological studies. The second group proved the efficiency of the selected parameters. Vessel welding was obtained with 100 mW, 3 seconds, continuous mode (fluence equals 950 J/cm², irradiance equals 320 W/cm²) for a mean temperature of 77 degree(s)C corresponding to collagen denaturation. In the second group the patency rate was 93% (28/30) with 3 pseudo-aneurisms and 2 thromboses. Histological studies noted slight modifications of the media.

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Veronique L. Martinot, Serge R. Mordon, Valerie A. Mitchell, P. N. Pellerin, and Jean Marc Brunetaud "Determination of optimal parameters for argon-laser-assisted carotid anastomoses in rats: macroscopic, thermal, and histological evaluation", Proc. SPIE 1879, Lasers in Urology, Gynecology, and General Surgery, (28 May 1993); https://doi.org/10.1117/12.146237

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