Fiber optic spectroscopy of blood for oxygen saturation sensor development: hematocrit effect

Charles D. Anderson; Marek T. Wlodarczyk

doi:10.1117/12.144840

21 May 1993 Fiber optic spectroscopy of blood for oxygen saturation sensor development: hematocrit effect

Charles D. Anderson, Marek T. Wlodarczyk

Proceedings Volume 1886, Fiber Optic Sensors in Medical Diagnostics; (1993) https://doi.org/10.1117/12.144840
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

We present experimental results from fiberoptic spectroscopy apparatus measuring whole blood's optical attenuation over a continuous wavelength range of 0.6 - 1.0 micrometers . Relative optical density (OD) spectra at a number of hematocrit values and oxygenation levels is obtained. The role of hematocrit in affecting spectral shape is discussed based upon relatively simple relationships derived from experimental data. A specific partial differential equation emerges from the analysis. This equation relates scatter-dependent experimental OD to oxygen saturation, hematocrit and purely absorbing, nonscattering constituents--and is obeyed over an extended wavelength range. A three-wavelength algorithm using experimental absorbances at LED-compatible wavelengths accurately provides both hematocrit and oxygen saturation values, for hematocrit levels between 0.2 and 0.6 in the presence of oxygenated and reduced Hb species. Optical system comparison between spectroscopic data and modeled LED behavior indicates the algorithm can be mapped to the design and implementation of discrete components for clinical use.

Citation Download Citation

Charles D. Anderson and Marek T. Wlodarczyk "Fiber optic spectroscopy of blood for oxygen saturation sensor development: hematocrit effect", Proc. SPIE 1886, Fiber Optic Sensors in Medical Diagnostics, (21 May 1993); https://doi.org/10.1117/12.144840

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