Light-emitting diode arrays and photodynamic therapy: a progress report

Kenneth J. Schlager; Richard C. Straight

doi:10.1117/12.180731

28 July 1994 Light-emitting diode arrays and photodynamic therapy: a progress report

Kenneth J. Schlager, Richard C. Straight

Proceedings Volume 2131, Biomedical Fiber Optic Instrumentation; (1994) https://doi.org/10.1117/12.180731
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

A laboratory version of an LED-array light source centered at 664 nm was reviewed last year in Biomedical Optics '93. Since that time, primary development efforts have been directed toward the development of two LED-array light sources for preclinical trials, one centered at 630 nm and the other at 800 nm. The first array is targeted as an alternative to the argon- pumped dye laser for photodynamic therapy (PDT) procedures based on the Photofrin II photosensitizer. The second array at 800 nm is directed at deep tissue penetration with a new photosensitizer recently developed at the University of Utah, bacteriochlorin derivative (bcd). While the first array is viewed as a lower-cost, more reliable, user-friendly replacement for traditional PDT dye lasers, the second is being developed in unison with bcd to significantly expand the range of applications of PDT to previously undeveloped cancer treatment modalities such as breast cancer. The 800 nm array has demonstrated an optical output of 5.13 watts while the 630 nm source radiates with a maximum optical power output of 1.63 watts.

Citation Download Citation

Kenneth J. Schlager and Richard C. Straight "Light-emitting diode arrays and photodynamic therapy: a progress report", Proc. SPIE 2131, Biomedical Fiber Optic Instrumentation, (28 July 1994); https://doi.org/10.1117/12.180731

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