Silicon naphthalocyanines derivatives: delivery systems as modulators of pharmacokinetics and photodynamic therapy (PDT) outcomes

Martha Kreimer-Birnbaum; Maria M. Zuk; Boris D. Rihter; Malcolm E. Kenney; Michael A. J. Rodgers

doi:10.1117/12.230976

31 January 1996 Silicon naphthalocyanines derivatives: delivery systems as modulators of pharmacokinetics and photodynamic therapy (PDT) outcomes

Martha Kreimer-Birnbaum, Maria M. Zuk, Boris D. Rihter, Malcolm E. Kenney, Michael A. J. Rodgers

Author Affiliations +

Proceedings Volume 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities; (1996) https://doi.org/10.1117/12.230976
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

Photodynamic therapy of neoplastic tissues is a new treatment modality that combines the in- vivo administration of a photosensitizer followed by its excitation with visible light, which leads to a photochemical reaction and tissue destruction. Naphthalocyanine derivatives are a class of second-generation photosensitizers that have excellent prospects as photodynamic therapeutic agents. Relevant to these types of applications are their photochemical properties, their tumor-localizing abilities, and their ability to elicit photodynamic responses. Bis(di- isobutyloctadecylsiloxy)silicon 2,3-naphthalocyanine (isoBOSINC) illustrates some of the above promising photoproperties: absorption in the red at 776 nm with an extinction coefficient greater than 10⁵ M^-1 cm^-1, a triplet state lifetime of 331 microseconds and singlet oxygen yields of approximately 0.20. Due to their high degree of hydrophobicity, metallonaphthalocyanines require a variety of approaches before they can be administered to cells in vitro or injected in vivo. One approach is the selection of solubilizing agents or vehicles such as a solution of Tween 80 in saline or emulsions of Cremophor EL in saline. This paper describes studies in (a) drug uptake by tumors and other tissues as a function of isoBOSINC's dose; (b) drug levels in normal versus tumor-bearing rats; (c) in-vitro photostability of isoBOSINC; (d) effects of delivery systems on photosensitizer tissue levels and pharmacokinetics, and PDT outcome.

Citation Download Citation

Martha Kreimer-Birnbaum, Maria M. Zuk, Boris D. Rihter, Malcolm E. Kenney, and Michael A. J. Rodgers "Silicon naphthalocyanines derivatives: delivery systems as modulators of pharmacokinetics and photodynamic therapy (PDT) outcomes", Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); https://doi.org/10.1117/12.230976

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available