Paper
2 April 1996 Photodynamic therapy using a diode laser with mono-L-aspartyl chlorin e6 (NPe6)
Kinya Furukawa M.D., Tohichiro Katsumi, Hiroshi Shibuya, Tetsuya Okunaka, Yukari Kuroiwa, Yoshiteru Ii, Akira Kaneda, Kouichi Saito, Chimori Konaka, Katsuo Aizawa, Harubumi Kato M.D.
Author Affiliations +
Abstract
The authors developed a new high-power red laser diode system (Matsushita Industrial Equipment Co., Ltd., Osaka) for photodynamic therapy (PDT) with mono-L-aspartyl chlorin e6 (NPe6, Meiji Seika Kaisha LTD.). The laser wavelength was adjusted to 664 nm and the power output could be varied in the range of 50-500 mW at the fiber tip in a continuous wave (cw) mode. The delivered energy could be adjusted from 50 - 1000 J. The system has a size of 49 by 20 by 40 cm, weighs 20 kg, and is readily portable. It runs on 100 V current. The laser power is easily controlled and the wavelength is stable (less than plus or minus 0.2 nm). The output beam is delivered via a quartz fiber. Furthermore, the full width at half-maximum power is less than 2 nm, which enables uniform, high-density photoirradiation. The power density distribution of the laser, analyzed by a CCD camera, was uniform throughout the photoirradiated field. In an animal study, tumor-bearing Balb/c mice were treated with the diode laser 5 hours after intravenous administration of NPe6 at a dose of 1.25 to 12.5 mg/kg i.v.. Total photoirradiation ranged from 3.13 to 250 J/cm2 which the energy density was adjusted to 100 mW/cm2. Percentages of cures were determined histopathologically from numbers of mice apparently disease-free 1 week after treatment. The results show that a laser energy of more than 12.5 J/cm2 was necessary to obtain 90% tumor cure rate at a maximum dose of NPe6 (12.5 mg/kg) and NPe6 dose of more than 2.5 mg/kg was necessary to obtain 90% cure rate at high laser energy of 200 J/cm2.
© (1996) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Kinya Furukawa M.D., Tohichiro Katsumi, Hiroshi Shibuya, Tetsuya Okunaka, Yukari Kuroiwa, Yoshiteru Ii, Akira Kaneda, Kouichi Saito, Chimori Konaka, Katsuo Aizawa, and Harubumi Kato M.D. "Photodynamic therapy using a diode laser with mono-L-aspartyl chlorin e6 (NPe6)", Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); https://doi.org/10.1117/12.237541
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KEYWORDS
Photodynamic therapy

Semiconductor lasers

Tumors

Laser energy

Laser systems engineering

Continuous wave operation

Laser therapeutics

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