Application of the new methodology of quantitative evaluation of morphofunctional changes in RBCs induced by low-dose irradiation of donors

Alexander V. Priezzhev; Andrey A. Dergachev; Victor F. Kopylov; Alexander V. Zhukotsky; Elena B. Lomakina; Emmanuil M. Kogan

doi:10.1117/12.239521

10 May 1996 Application of the new methodology of quantitative evaluation of morphofunctional changes in RBCs induced by low-dose irradiation of donors

Alexander V. Priezzhev, Andrey A. Dergachev, Victor F. Kopylov, Alexander V. Zhukotsky, Elena B. Lomakina, Emmanuil M. Kogan

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Proceedings Volume 2678, Optical Diagnostics of Living Cells and Biofluids; (1996) https://doi.org/10.1117/12.239521
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

We are reporting on the results obtained in the development of our previous paper. We have implemented the previously described unified approach of particle image velocimetry and computer morphodensitometry trying to find correlation between morphofunctional and dynamic parameters of red blood cells of human donors who had undergone low-doze ionizing irradiation conventionally used in radiology. Specifically we examined the suspension of RBCs obtained from children who had accidentally or therapeutically undergone irradiation with different doses (0.03-0.04 Gy), and compared them to controls. Our experiments have shown the existence of correlation between the rheological and morphometric indexes obtained with the help of the computer image processing system Diamorph.

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Alexander V. Priezzhev, Andrey A. Dergachev, Victor F. Kopylov, Alexander V. Zhukotsky, Elena B. Lomakina, and Emmanuil M. Kogan "Application of the new methodology of quantitative evaluation of morphofunctional changes in RBCs induced by low-dose irradiation of donors", Proc. SPIE 2678, Optical Diagnostics of Living Cells and Biofluids, (10 May 1996); https://doi.org/10.1117/12.239521

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KEYWORDS

Blood

Image processing

Particles

Computing systems

Image filtering

Particle image velocimetry

Diagnostics

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