Vertical cavity surface-emitting laser scanning cytometer for high-speed analysis of cells

Paul Lee Gourley; Anthony E. McDonald; Mark F. Gourley M.D.

doi:10.1117/12.237581

5 April 1996 Vertical cavity surface-emitting laser scanning cytometer for high-speed analysis of cells

Paul Lee Gourley, Anthony E. McDonald, Mark F. Gourley M.D.

Proceedings Volume 2679, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III: Optical Biopsy; (1996) https://doi.org/10.1117/12.237581
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

We have constructed a new semiconductor laser device that may be useful in high speed characterization of cell morphology for diagnosis of disease. This laser device has critical advantages over conventional cell florescence detection methods since it provides intense, monochromatic, low-divergence light signals that are emitted from lasing modes confined by a cell. Further, the device integrates biological structures with semiconductor materials at the wafer level to reduce device size and simplify cell preparation. In this paper we discuss operational characteristics of the prototype cytometer and present preliminary data for blood cells and dielectric spheres.

Citation Download Citation

Paul Lee Gourley, Anthony E. McDonald, and Mark F. Gourley M.D. "Vertical cavity surface-emitting laser scanning cytometer for high-speed analysis of cells", Proc. SPIE 2679, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III: Optical Biopsy, (5 April 1996); https://doi.org/10.1117/12.237581

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