Investigations of physical model of biological tissue

Kirill G. Linkov; Gennady L. Kisselev; Victor B. Loschenov

doi:10.1117/12.260723

5 December 1996 Investigations of physical model of biological tissue

Kirill G. Linkov, Gennady L. Kisselev, Victor B. Loschenov

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Proceedings Volume 2923, Laser-Tissue Interaction and Tissue Optics II; (1996) https://doi.org/10.1117/12.260723
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

Physical model of a biological tissue for comparison with earlier created mathematical model of a biological tissue and researches of distribution photosensitizer in a depth was created and investigated. Mathematical model is based on granulated representation of optical medium. The model of a biological tissue was created on the basis of enough thin layers of a special material. For fluorescence excitation laser sources with a various wavelength were used. For investigation of scattering and fluorescent signal laser- fiber spectrum-analyzer LESA-5 was applied. Water solution of aluminum phthalocyanine and oil solution of zinc phthalocyanine were used for receiving of fluorescent signal. Created samples have certain absorbing and fluorescent properties. Scattering properties of samples are close to scattering properties of real human skin. By virtue of layered structure the model permits to simulate as a biological tissue without photosensitizer accumulation in it, as tissue with photosensitizer accumulation with certain distribution in a depth. Dependence of fields distribution on a surface was investigated at change of parameters of a model. Essential changes of distribution on a surface depending on the characteristics of model was revealed. The space and angular characteristics was investigated also. The investigations with physical model correspond to predicted results of theoretical model.

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Kirill G. Linkov, Gennady L. Kisselev, and Victor B. Loschenov "Investigations of physical model of biological tissue", Proc. SPIE 2923, Laser-Tissue Interaction and Tissue Optics II, (5 December 1996); https://doi.org/10.1117/12.260723

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KEYWORDS

Scattering

Tissue optics

Tissues

Mathematical modeling

Laser scattering

Luminescence

Optical properties

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