Multislice 1H magnetic resonance spectroscopic imaging: assessment of epilepsy, Alzheimer's disease, and amyotrophic lateral sclerosis

Michael W. Weiner; Andrew A. Maudsley; Norbert Schuff; Brian J. Soher; Peter P. Vermathen; George Fein; Kenneth D. Laxer

doi:10.1117/12.312565

3 July 1998 Multislice ¹H magnetic resonance spectroscopic imaging: assessment of epilepsy, Alzheimer's disease, and amyotrophic lateral sclerosis

Michael W. Weiner, Andrew A. Maudsley, Norbert Schuff, Brian J. Soher, Peter P. Vermathen, George Fein, Kenneth D. Laxer

Author Affiliations +

Proceedings Volume 3337, Medical Imaging 1998: Physiology and Function from Multidimensional Images; (1998) https://doi.org/10.1117/12.312565
Event: Medical Imaging '98, 1998, San Diego, CA, United States

Abstract

Proton magnetic resonance spectroscopic imaging (1H MRSI) with volume pre-selection (i.e. by PRESS) or multislice 1H MRSI was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice 1H MRSI of the human brain, without volume pre-selection offers considerable advantages over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectra curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtaining full brain coverage and data acquisition at short spin echo times (TE less than 30 ms) for the detection of metabolites with short T2 relaxation times.

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Michael W. Weiner, Andrew A. Maudsley, Norbert Schuff, Brian J. Soher, Peter P. Vermathen, George Fein, and Kenneth D. Laxer "Multislice ¹H magnetic resonance spectroscopic imaging: assessment of epilepsy, Alzheimer's disease, and amyotrophic lateral sclerosis", Proc. SPIE 3337, Medical Imaging 1998: Physiology and Function from Multidimensional Images, (3 July 1998); https://doi.org/10.1117/12.312565

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