Control of metastatic mammary tumors by laser immunotherapy through local treatment

Wei R. Chen; Robert E. Nordquist

doi:10.1117/12.317882

7 August 1998 Control of metastatic mammary tumors by laser immunotherapy through local treatment

Wei R. Chen, Robert E. Nordquist

Author Affiliations +

Proceedings Volume 3548, Biomedical Optics and Lasers: Diagnostics and Treatment; (1998) https://doi.org/10.1117/12.317882
Event: Photonics China '98, 1998, Beijing, China

Abstract

Malignant tumors kill hosts almost entirely by tumor invasion to multiple sites including vital organs. These metastases are often difficult to detect and when detected it is usually too late for effective treatment. Therefore, control of metastatic tumors is by far the biggest challenge in cancer treatment. Can the metastases be prevented or eradicated by a treatment of local tumor that can be easily detected and treated? It apparently requires a systemic reaction, usually a tumor- specific immune response. Laser immunotherapy, a novel approach using laser, photosensitizer and immunoadjuvant, has shown the potential to achieve such an immune reaction. This new method was applied in treatment of rat metastatic mammary tumors. The tumor model is DMBA-4, an aggressive tumor that invades different sites through blood vessels and lymphatics. Without treatment, all the tumor-bearing rats died with an average survival time of less than 35 days. Remote metastases were observed in all late-stage tumor-bearing rats. Laser immunotherapy was capable of eradicating treated primary tumors, and more importantly, the metastases at remote sites were also eradicated without direct treatment. The probable mechanism is an induced tumor-specific immune response, and this hypothesis has been supported by several immunoassays. This new therapy may prove to be an effective treatment modality for metastatic tumors by a non-invasive local laser application.

Citation Download Citation

Wei R. Chen and Robert E. Nordquist "Control of metastatic mammary tumors by laser immunotherapy through local treatment", Proc. SPIE 3548, Biomedical Optics and Lasers: Diagnostics and Treatment, (7 August 1998); https://doi.org/10.1117/12.317882

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