Capabilities of optical coherence tomography in laryngology

Andrei Shakhov; Anna Terentjeva; Natalia D. Gladkova; Ludmila Snopova; Yuri Chumakov; Felix I. Feldchtein; Valentin M. Gelikonov; Grigory V. Gelikonov; Alexander M. Sergeev

doi:10.1117/12.350971

22 June 1999 Capabilities of optical coherence tomography in laryngology

Andrei Shakhov, Anna Terentjeva, Natalia D. Gladkova, Ludmila Snopova, Yuri Chumakov, Felix I. Feldchtein, Valentin M. Gelikonov, Grigory V. Gelikonov, Alexander M. Sergeev

Author Affiliations +

Proceedings Volume 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX; (1999) https://doi.org/10.1117/12.350971
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

We present first result of using the optical coherence tomography (OCT) in complex clinical studies in laryngology. Mucosa of the upper and middle portions of larynx is of special interest for OCT applications: it is clinically important, easily accessed by an endoscopic OCT probe, and possesses a well defined and rich tomographic structure. We have examined several tens of patients with abnormalities in vocal folds. The diagnosis was made based on clinical data including laryngoscopy and finally confirmed morphologically. When examining larynx mucosa, an endoscopic OCT probe has been introduced through a standard laryngoscope lumen, so that OCT imaging has been performed in parallel with visual observation. The OCT studies have demonstrated that in comparison with stratified healthy mucosa, carcinomatous regions have no tomographically differentiated structure, thus allowing one to exactly define the border of a tumor. Vocal nodules are imaged as poorly scattering regions without clear boundaries under preserved epithelium. Cysts of gland mucosa are seen with OCT as sharply delineated shadows at the depth of several hundred micrometers. We have also examined several patients with carcinoma after a course of radiation therapy and observed different changes in OCT images of adjoining epithelium corresponding to metaplasia, hyperplasia, and sclerosis.

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Andrei Shakhov, Anna Terentjeva, Natalia D. Gladkova, Ludmila Snopova, Yuri Chumakov, Felix I. Feldchtein, Valentin M. Gelikonov, Grigory V. Gelikonov, and Alexander M. Sergeev "Capabilities of optical coherence tomography in laryngology", Proc. SPIE 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX, (22 June 1999); https://doi.org/10.1117/12.350971

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