Wound repair in rat urinary bladder following electrocautery or holmium laser incision

Giordano Venzi M.D.; Franz R. Schmidlin M.D.; Giulio Gabbiani; Guy P. Delacretaz; Brigitte Pittet; Hans-Juerg Leisinger M.D.; Christoph E. Iselin M.D.

doi:10.1117/12.350961

22 June 1999 Wound repair in rat urinary bladder following electrocautery or holmium laser incision

Giordano Venzi M.D., Franz R. Schmidlin M.D., Giulio Gabbiani, Guy P. Delacretaz, Brigitte Pittet, Hans-Juerg Leisinger M.D., Christoph E. Iselin M.D.

Author Affiliations +

Proceedings Volume 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX; (1999) https://doi.org/10.1117/12.350961
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Woundhealing is a complex phenomenon which varies according the type of tissue but is also depending from the type of tissue injury. Electrocautery mainly induces coagulation necrosis while thermal damages induced by the Holmium laser primarily lead to tissue vaporization which may induce less tissue injury. The aim of this study was to evaluate the healing process of the Holmium laser induced lesions compared to electrocautery induced lesions in urothelial tissue by assessing the inflammatory response and myofibroblast behavior in sequential healing phases. A surgical wound was created in the urinary rat bladder of 32 rats either by electrocautery or by laser (N=16). The inflammatory response, the total lesion depth and the myofibroblast activity during woundhealing was then analyzed on a qualitative basis on days 0/2/4/8. The overall inflammatory response was comparable in both groups up to days two and four. However, at day eight less cellular inflammatory reaction and less myofibroblast activity was found in the specimen of lesions created by the Holmium laser. These results suggest that wound repair may be a less invasive process after Holmium laser than electrocautery.

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Giordano Venzi M.D., Franz R. Schmidlin M.D., Giulio Gabbiani, Guy P. Delacretaz, Brigitte Pittet, Hans-Juerg Leisinger M.D., and Christoph E. Iselin M.D. "Wound repair in rat urinary bladder following electrocautery or holmium laser incision", Proc. SPIE 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX, (22 June 1999); https://doi.org/10.1117/12.350961

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KEYWORDS

Holmium

Laser tissue interaction

Bladder

Laser therapeutics

Tissues

Wound healing

Laser energy

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