Improved accuracy of quantification of analytes in human body fluids by near-IR laser Raman spectroscopy with new algorithms

Jianan Y. Qu; On Lai Yau; SzeFong Mark Yau

doi:10.1117/12.351525

9 July 1999 Improved accuracy of quantification of analytes in human body fluids by near-IR laser Raman spectroscopy with new algorithms

Jianan Y. Qu, On Lai Yau, SzeFong Mark Yau

Author Affiliations +

Proceedings Volume 3595, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems; (1999) https://doi.org/10.1117/12.351525
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Near infrared Raman spectroscopy has been successfully used to analyze ethanol and acetaminophen in human urine samples quantitatively. The new algorithms incorporating the intrinsic spectrum of the analyte of interest into the multivariate calibration were examined to improve the accuracy of the predicted concentrations. Comparing with commonly used partial least squares calibration, it was found that the methods using the intrinsic spectrum of the analyte of interest always achieved much higher accuracy, particularly when the interference from other undesired chemicals in the samples are severe.

Citation Download Citation

Jianan Y. Qu, On Lai Yau, and SzeFong Mark Yau "Improved accuracy of quantification of analytes in human body fluids by near-IR laser Raman spectroscopy with new algorithms", Proc. SPIE 3595, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems, (9 July 1999); https://doi.org/10.1117/12.351525

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