13CO2/12CO2 ratio analysis in exhaled air by lead-salt tunable diode lasers for noninvasive diagnostics in gastroenterology

Eugene V. Stepanov; Pavel V. Zyrianov; Valerii A. Miliaev; Yurii G. Selivanov; Eugene G. Chizhevskii; Svetlana Os'kina; Vladimir T. Ivashkin; Elena I. Nikitina

doi:10.1117/12.353109

14 July 1999 ¹³CO₂/¹²CO₂ ratio analysis in exhaled air by lead-salt tunable diode lasers for noninvasive diagnostics in gastroenterology

Eugene V. Stepanov, Pavel V. Zyrianov, Valerii A. Miliaev, Yurii G. Selivanov, Eugene G. Chizhevskii, Svetlana Os'kina, Vladimir T. Ivashkin, Elena I. Nikitina

Author Affiliations +

Proceedings Volume 3829, ALT'98 Selected Papers on Novel Laser Methods in Medicine and Biology; (1999) https://doi.org/10.1117/12.353109
Event: Selected Papers from Seventh International Conference on Advanced Laser Technologies (ALT'98): Laser Methods in Medicine and Biology, 1998, Tallin, Estonia

Abstract

An analyzer of ¹³CO₂/¹²CO₂ ratio in exhaled air based on lead-salt tunable diode lasers is presented. High accuracy of the carbon isotope ratio detection in exhaled carbon dioxide was achieved with help of very simple optical schematics. It was based on the use of MBE laser diodes operating in pulse mode and on recording the resonance CO₂ absorption at 4.2 micrometers . Special fast acquisition electronics and software were applied for spectral data collection and processing. Developed laser system was tested in a clinical train aimed to assessment eradication efficiency in therapy of gastritis associated with Helicobacter pylori infection. Data on the ¹³C-urea breath test used for P.pylori detection and obtained with tunable diode lasers in the course of the trail was compared with the results of Mass-Spectroscopy analysis and histology observations. The analyzer can be used also for ¹³CO₂/¹²CO₂ ratio detection in exhalation to perform gastroenterology breath test based on using other compounds labeled with stable isotopes.

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Eugene V. Stepanov, Pavel V. Zyrianov, Valerii A. Miliaev, Yurii G. Selivanov, Eugene G. Chizhevskii, Svetlana Os'kina, Vladimir T. Ivashkin, and Elena I. Nikitina "¹³CO₂/¹²CO₂ ratio analysis in exhaled air by lead-salt tunable diode lasers for noninvasive diagnostics in gastroenterology", Proc. SPIE 3829, ALT'98 Selected Papers on Novel Laser Methods in Medicine and Biology, (14 July 1999); https://doi.org/10.1117/12.353109

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