Engineered matrices for bone regeneration

Shelley R. Winn; Yunhua Hu; Amy Pugh; Leanna Brown; Jesse T. Nguyen; Jeffrey O. Hollinger D.D.S.

doi:10.1117/12.388078

13 June 2000 Engineered matrices for bone regeneration

Shelley R. Winn, Yunhua Hu, Amy Pugh, Leanna Brown, Jesse T. Nguyen, Jeffrey O. Hollinger D.D.S.

Author Affiliations +

Proceedings Volume 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical; (2000) https://doi.org/10.1117/12.388078
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Traditional therapies of autografts and allogeneic banked bone can promote reasonable clinical outcome to repair damaged bone. However, under certain conditions the success of these traditional approaches plummets, providing the incentive for researchers to develop clinical alternatives. The evolving field of tissue engineering in the musculoskeletal system attempts to mimic many of the components from the intact, healthy subject. Those components consist of a biologic scaffold, cells, extracellular matrix, and signaling molecules. The bone biomimetic, i.e., an engineered matrix, provides a porous structural architecture for the regeneration and ingrowth of osseous tissue at the site of injury. To further enhance the regenerative cascade, our strategy has involved porous biodegradable scaffolds containing and releasing signaling molecules and providing a suitable environment for cell attachment, growth and differentiation. In addition, the inclusion of genetically modified osteogenic precursor cells has brought the technology closer to developing a tissue-engineered equivalent. The presentation will describe various formulations and the methods utilized to evaluate the clinical utility of these biomimetics.

Citation Download Citation

Shelley R. Winn, Yunhua Hu, Amy Pugh, Leanna Brown, Jesse T. Nguyen, and Jeffrey O. Hollinger D.D.S. "Engineered matrices for bone regeneration", Proc. SPIE 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical, (13 June 2000); https://doi.org/10.1117/12.388078

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KEYWORDS

Bone

Foam

Tissues

Matrices

Biomimetics

Polymers

Mercury

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