Investigation of the aggregation and disaggregation properties of erythrocytes by light-scattering measurements

Juergen Lademann; Hans-Juergen Weigmann; Wolfram Sterry; Holger Kiesewetter; Andre Roggan; Gerhard J. Mueller; Alexander V. Priezzhev; Nikolai N. Firsov

doi:10.1117/12.387142

31 May 2000 Investigation of the aggregation and disaggregation properties of erythrocytes by light-scattering measurements

Juergen Lademann, Hans-Juergen Weigmann, Wolfram Sterry, Holger Kiesewetter, Andre Roggan, Gerhard J. Mueller, Alexander V. Priezzhev, Nikolai N. Firsov

Author Affiliations +

Proceedings Volume 3923, Optical Diagnostics of Biological Fluids V; (2000) https://doi.org/10.1117/12.387142
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

The aggregation and disaggregation behavior of erythrocytes reflects pathological states of the human body. The investigation of the aggregation and disaggregation process of human blood samples by laser spectroscopic measurements is described int he present paper. The whole blood samples were analyzed using a rotating coaxial cylinder system in combination with a special method for data processing. The erythrocyte aggregates were destroyed completely without injuring the cell membranes by shear forces arising during the cylinder rotation. The time behavior of the remission signal during the aggregation process was investigated. The disaggregation process was characterized by the dependence of the remission signal intensity on different applied shear rates.

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Juergen Lademann, Hans-Juergen Weigmann, Wolfram Sterry, Holger Kiesewetter, Andre Roggan, Gerhard J. Mueller, Alexander V. Priezzhev, and Nikolai N. Firsov "Investigation of the aggregation and disaggregation properties of erythrocytes by light-scattering measurements", Proc. SPIE 3923, Optical Diagnostics of Biological Fluids V, (31 May 2000); https://doi.org/10.1117/12.387142

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