High-throughput pharmocology system HT-PS 100: instrument for automated quantitative analysis of a ligand-receptor interaction based on ligand concentration-dependent functional responses in cells

Ilya Okun; Gregory V. Kaler; Michael Otto; Alex Okun

doi:10.1117/12.384244

26 April 2000 High-throughput pharmocology system HT-PS 100: instrument for automated quantitative analysis of a ligand-receptor interaction based on ligand concentration-dependent functional responses in cells

Ilya Okun, Gregory V. Kaler, Michael Otto, Alex Okun

Author Affiliations +

Proceedings Volume 3924, Molecular Imaging: Reporters, Dyes, Markers, and Instrumentation; (2000) https://doi.org/10.1117/12.384244
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Contrary to conventionally used serial discrete dilutions of a ligand to construct concentration-response curves with a few experimental points, we describe here an automated system, HT-PS^TM 100, that produces continuous ligand concentration gradients for interrogating cells in flow, and concurrently measures the ligand-induced functional response.

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Ilya Okun, Gregory V. Kaler, Michael Otto, and Alex Okun "High-throughput pharmocology system HT-PS 100: instrument for automated quantitative analysis of a ligand-receptor interaction based on ligand concentration-dependent functional responses in cells", Proc. SPIE 3924, Molecular Imaging: Reporters, Dyes, Markers, and Instrumentation, (26 April 2000); https://doi.org/10.1117/12.384244

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