Measurement of the refractive index and aggregation of erythrocytes by the laser diffractometry method

Stanislav S. Bessmeltsev; Alexander V. Lendiaev; A. U. Moskaleva; Vladimir Alexeevich Tarlykov; Irina G. Hodus

doi:10.1117/12.484499

29 July 2002 Measurement of the refractive index and aggregation of erythrocytes by the laser diffractometry method

Stanislav S. Bessmeltsev, Alexander V. Lendiaev, A. U. Moskaleva, Vladimir Alexeevich Tarlykov, Irina G. Hodus

Proceedings Volume 4900, Seventh International Symposium on Laser Metrology Applied to Science, Industry, and Everyday Life; (2002) https://doi.org/10.1117/12.484499
Event: Seventh International Symposium on Laser Metrology Applied to Science, Industry, and Everyday Life, 2002, Novosibirsk, Russian Federation

Abstract

The purpose of the present work is the experimental research of the possibility to use the laser diffraction method for determination of erythrocytes aggregation, erythrocyte refractive index and study of magnetic field influence on the erythrocytes (in vitro) in patients with multiple myeloid diseases. Changes in the refractive index of erythrocytes in patients with multiple myeloid and donors were experimentally analyzed by diffractometry. Essential differences in the refractive index ofMM patients and healthy persons were identified. Control measurements of erythrocytes aggregation degree were taken by microscopic method. Blood of 1 6 patients was studied. An increase in erythrocytes aggregation degree from 81 up to 99% was initially registered in all patients (average value is 90±3%). The influence of a permanent magnetic field on the erythrocytes (in vitro) was observed, for which purpose 3 sets of tests were conducted: in 8 of them a decrease in the aggregation degree from 3 up to 1 6 % was registered;in 4 tests no change was detected, while in 4 other tests an increase in the aggregation degree from 2 up to 13% was detected. The average value of the erythrocytes aggregation degree after the application of magnetic field was 93±8%. The obtained data serve as evidence to the positive influence of the permanent magnetic field on the erythrocytes aggregation as a whole, however the mechanism of such influence remains unclear. The undertaken research has proved the laser diffraction method to be perspective in medicine.

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Stanislav S. Bessmeltsev, Alexander V. Lendiaev, A. U. Moskaleva, Vladimir Alexeevich Tarlykov, and Irina G. Hodus "Measurement of the refractive index and aggregation of erythrocytes by the laser diffractometry method", Proc. SPIE 4900, Seventh International Symposium on Laser Metrology Applied to Science, Industry, and Everyday Life, (29 July 2002); https://doi.org/10.1117/12.484499

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KEYWORDS

Refractive index

Diffraction

Magnetism

Fractal analysis

Blood

Mie scattering

Light scattering

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