Determination of instrumental precision requirement for expected glucose prediction accuracy

Qingbo Li; Xiaotang Hu; Kexin Xu

doi:10.1117/12.483008

12 September 2002 Determination of instrumental precision requirement for expected glucose prediction accuracy

Qingbo Li, Xiaotang Hu, Kexin Xu

Proceedings Volume 4916, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment; (2002) https://doi.org/10.1117/12.483008
Event: Photonics Asia, 2002, Shanghai, China

Abstract

Noninvasive measurement of blood glucose is a focal topic in the biomedical engineering field, but no success has been achieved completely as yet. The necessary instrumental precision (i.e., instrumental repeatability signal-to-noise ratio) is prerequisite for the desired prediction accuracy, which have not been investigated systematically. The mathematic relations regarding instrumental precision, regression method and prediction accuracy are put forward. They are tested and analyzed through the determination of glucose concentration in an aqueous solution with near-infrared (NIR) spectroscopy and chemometrics. The results show that the mathematic relations provide a estimate method of prediction accuracy for spectroscopic measurement. In addition, they can determine the necessary instrumental requirement for the expected prediction accuracy when certain regression method is used. This provides theoretic guides to the measuring methods design and references to the prediction accuracy analysis of the noninvasive glucose measurement and even the near-infrared spectroscopy.

Citation Download Citation

Qingbo Li, Xiaotang Hu, and Kexin Xu "Determination of instrumental precision requirement for expected glucose prediction accuracy", Proc. SPIE 4916, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment, (12 September 2002); https://doi.org/10.1117/12.483008

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